2. Signaling Pathways
  3. Neuronal Signaling
  4. Monoamine Oxidase

Monoamine Oxidase

MAO

Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase Isoform Specific Products:

Monoamine Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10399A
    Ladostigil hydrochloride
    		Inhibitor 99.94%
    Ladostigil (TV-3326) hydrochloride is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO), with IC50s of 37.1 and 31.8 μM for MAO-B and AChE, respectively. Ladostigil hydrochloride exhibits neuroprotective, antioxidant and anti-inflammatory activities. Ladostigil can be used for the research of depression and Alzheimer's disease. Ladostigil (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Ladostigil hydrochloride
  • HY-14200
    (S)-Rasagiline
    		Inhibitor 99.80%
    (S)-Rasagiline (TVP1022) is the relatively inactive S-enantiomer form of Rasagiline. Rasagiline is a highly potent selective irreversible MAO inhibitor with IC50s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively. (S)-Rasagiline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (S)-Rasagiline
  • HY-19915B
    Contezolid acefosamil sodium
    		Inhibitor
    Contezolid acefosamil sodium (MRX-4), a new and orally active oxazolidinone, is an antibiotic in study for complicated skin and soft tissue infections (cSSTI) caused by resistant Gram-positive bacteria. Contezolid acefosamil sodium (MRX-4) markedly reduces potential for myelosuppression and monoamine oxidase inhibition (MAOI).
    Contezolid acefosamil sodium
  • HY-100975
    TB5
    		Inhibitor 99.96%
    TB5 is a potent, selective and reversible inhibitor of hMAO-B with a Ki value of 0.11±0.01 μM.
    TB5
  • HY-151466
    HIF-1α-IN-5
    		Inhibitor 99.95%
    HIF-1α-IN-5 is a HIF-1α inhibitor with an IC50 value of 24 nM (in HEK293T cell). HIF-1α-IN-5 also inhibits MAO-A activity. HIF-1α-IN-5 downregulates VEGF and PDK1 mRNA expressions under hypoxia. HIF-1α-IN-5 can be used in the research of cancer.
    HIF-1α-IN-5
  • HY-122812
    Maesopsin
    		Inhibitor 99.66%
    Maesopsin is a phenolic compound, that can be isolated from Hoveniae Lignum.
    Maesopsin
  • HY-W653809
    Mephentermine hydrochloride
    		Inhibitor 98.52%
    Mephentermine hydrochloride significantly increases peripheral resistance. Derivatives of mephentermine hydrochloride are inhibitors of MAO-A/B and can be used in cardiovascular research.
    Mephentermine hydrochloride
  • HY-N0159R
    Paeonol (Standard)
    		Inhibitor
    Paeonol (Standard) is the analytical standard of Paeonol. This product is intended for research and analytical applications. Paeonol is an active extraction from the root of Paeonia suffruticosa, Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
    Paeonol (Standard)
  • HY-E70519
    Tyramine oxidase, Microorganism
    Tyramine oxidase, Microorganism (EC 1.4.3.4) is a copper enzyme found in the cytoplasm of animal cells that catalyzes the oxidation of phenolic amine substrates. Tyramine oxidase, Microorganism involves in the metabolism and clearance of phenolamine compounds and has an important role in maintaining homeostasis in vivo. Tyramine oxidase, Microorganism is promising for research of hypertension, asthma, and depression.
    Tyramine oxidase, Microorganism
  • HY-127109A
    Tisolagiline monomethylsulfate
    		Inhibitor 99.83%
    Tisolagiline methylsulfate (KDS2010) is the selective, reversible and orally active inhibitor for MAO-B with an IC50 of 8 nM. Tisolagiline methylsulfate exhibits neuroprotective and anti-neuroinflammatory activities.
    Tisolagiline monomethylsulfate
  • HY-D0004
    Azure B
    		Inhibitor 98.13%
    Azure B is a cationic dye and the major metabolite of Methylene blue. Azure B is used in making Azure eosin stains for blood smear staining. Azure B is a high-potency, selective and reversible inhibitor of monoamine oxidases (MAO)-A, with IC50s of 11 and 968 nM for recombinant human MAO-A and MAO-B, respectively. Azure B possesses significant antidepressant-like effects.
    Azure B
  • HY-14203
    (R)-Safinamide
    		Inhibitor 99.89%
    (R)-Safinamide, the enantiomer of safinamide (HY-70057), can inhibit MAO-B with an IC50 value of 0.45 μM.
    (R)-Safinamide
  • HY-151498A
    PXS-4787 hydrochloride
    		Inhibitor 99.71%
    PXS-4787 hydrochloride is a specific and effective pan-LOX (lysyl oxidase) inhibitor for abolishing lysyl oxidase activity. PXS-4787 hydrochloride inhibits LOX with IC50s of 2 μM (Bovine LOX), 3.2 μM (rh LOXL1), 0.6 μM (rh LOXL2), 1.4 μM (rh LOXL3), 0.2 μM (rh LOXL4), respectively. PXS-4787 hydrochloride reduces deposition and crosslinking of collagen I secreted by human fibroblasts.
    PXS-4787 hydrochloride
  • HY-W010130
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
    		Inhibitor 99.96%
    7-Hydroxy- 3, 4- dihydro- 2(1H) - quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B.
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
  • HY-N1965
    Gaultherin
    		Inhibitor 99.44%
    Gaultherin is an orally active non-steroidal anti-inflammatory agent. Gaultherin selectively inhibits NF-κB, MAPK, COX-2 (IC50 = 0.35 mg/mL), LOX (IC50 = 0.56 mg/mL) and HYAL (IC50 = 28.58 μg/mL) to exert anti-inflammatory, antipyretic and analgesic effects. Gaultherin exhibits modest direct antioxidant capacity, greater in cell-based models. Gaultherin does not affect COX-1 so that avoids the common gastrointestinal side effects of Aspirin (HY-14654).
    Gaultherin
  • HY-117173
    (Rac)-Rasagiline
    		Inhibitor
    (Rac)-Rasagiline (AGN1135) is the racemate of Rasagiline. (Rac)-Rasagiline is a selective type B MAO (MAO-B) inhibitor. (Rac)-Rasagiline can be used for Parkinson's disease research. (Rac)-Rasagiline protects against MPTP (HY-15608)-induced toxicity.
    (Rac)-Rasagiline
  • HY-101169
    Tetrindole mesylate
    		Inhibitor 99.93%
    Tetrindole mesylate is a selective inhibitor of monoamine oxidase A (MAO A). Tetrindole mesylate inhibits rat brain mitochondrial MAO A in a competitive manner with a Ki value of 0.4 μM and inhibits MAO B with a Ki of 110 μM. Tetrindole mesylate has antidepressant activity.
    Tetrindole mesylate
  • HY-14260
    RS 8359
    		Inhibitor
    RS 8359 is a selective and reversible MAO-A inhibitor, with antidepressant activity.
    RS 8359
  • HY-W087433
    Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate
    		Inhibitor 99.78%
    Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate is a potent and selective inhibitor of hMAO-B with an IC50 of 45.52 μM.
    Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate
  • HY-W655727
    (-)-2-Phenylpropylamine
    		Inhibitor
    (-)-2-Phenylpropylamine ((S)-2-Phenylpropylamine) (compound 3b) is a MAO-A and MAO-B inhibitor with Ki values of 584 μM and 156 μM, respectively.
    (-)-2-Phenylpropylamine
Cat. No. Product Name / Synonyms Application Reactivity
Monoamine Oxidase Isoform Comparison

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